To explore the roles of lipoprotein lipases in breast cancer, we performed in silico gene expression analysis of lipoprotein lipases, including lipoprotein lipase (LPL), hepatic lipase C (LIPC) and endothelial lipase G (LIPG), in breast cancer using the Oncomine cancer gene expression database (https://www.oncomine.org) (Rhodes et al., 2007). This evidence concerns the gene LPL and breast cancer.