More recently, noise exposure of rats was reported to adversely affect the cardiovascular system by increased levels of circulating stress hormones (e.g., corticosterone, adrenaline, noradrenaline, endothelin-1 [ET-1]) and negatively affected oxidative stress markers, such as increased malondialdehyde and decreased SOD, all of which point toward endothelial dysfunction [octave band noise: 80–100 dB(A), 8–16 kHz, 8 h/day for 20 days; 8 rats/group] (204). Here, EDN1 is linked to endothelial dysfunction.