Curcumin-CL NPs inhibited phosphorylation of p38, JNK, and tau protein in Aβ insulted neurons. WGA-curcumin-CL NPs substantially reduced Aβ plaque deposition and lowered AChE activity in the hippocampus of AD rats. (Kuo et al., 2017). This evidence concerns the gene ACHE and Alzheimer disease.