Positive staining for E‐cadherin was observed in cell membranes, and the expression level of E‐cadherin in bladder cancer tissue samples (18.6%, 19/102) was significantly lower than that in adjacent (53.9%, 55/102) and normal bladder tissue samples (76.4%, 81/106) (P < 0.001). The gene discussed is CDH1; the disease is urinary bladder cancer.