To our knowledge, only one earlier study focused on sepsis patients admitted to the ICU: in a randomized trial of 250 critically ill patients with severe sepsis, prior statin users had lower baseline levels of IL-6 compared to statin-naïve patients; treatment with atorvastatin during admission did not alter IL-6 levels compared to placebo in either prior statin users or statin-naïve patients [29]. This evidence concerns the gene IL6 and Sepsis.