RPN1 and neoplasm: Cluster 1 is shown containing proteins related to the folding and processing of proteins (HSP90B1, DNAJA1, CALR), transport of proteins (CLPB), proteins with special relevance in hypoxia-like HYOU1, the gene that encodes ORP150, that is overexpressed in many tumors and it is tightly correlated with invasion and tumor progression [28–30] and proteins involved in the glycosylation of proteins (RPN1, STT3A, MAGT1, and DDOST).