Of particular interest is cluster 19 containing proteins related to autophagy (ATG5, ATG7, SQSTM1), a homeostatic process that can function in both tumor and stromal cells under conditions of low input of nutrients; in tumors, it has also been related to therapeutic resistance to some antineoplastic agents such as tyrosine kinase inhibitors [31]. The gene discussed is ATG5; the disease is neoplasm.