The importance of interferons was highlighted in our previous results on the TLR4 signaling pathway, where TLR4, TICAM1, TICAM2, TBK1, IRF3, IFNA1, and IFNA2 mRNAs showed changes in the murine lupus-like models [7]. This evidence concerns the gene TLR4 and systemic lupus erythematosus.