In agreement, The Cancer Genome Atlas (TCGA), based on the high number of viral copies and high levels of viral gene expression, proposed the EBV-positive GC (also known as EBVaGC) as a particular GC entity characterized by DNA hypermethylation, increased frequency of PIK3CA, ARID1A, and BCOR mutations but wild-type p53, and high expression of T cell inhibitory molecules CD274 (PD-L1), PDCD1LG2 (PD-L2), and indoleamine 2,3-dioxygenase 1 (IDO 1) [10, 11]. Here, CD274 is linked to gastric cancer.