Furthermore, we recommend studying the relationship between APOE ε4 allele and the rapid progress of LOAD, the APOE ε4 risk in other Ecuadorian ethnicities, and other genetic and environmental susceptibilities which could be regulating the predisposition to LOAD, as well as the conduction of prevalence and incidence AD studies on the Ecuadorian population. This evidence concerns the gene APOE and Alzheimer disease.