Given the prognostic role of GPS in varying malignancies, including non-small cell lung cancer [10], gastric cancer [11], colorectal liver metastases [12], esophageal cancer [13], plus deep relationship of C-reactive protein in survival of patients with UTUC [14–16, 17], we attempted to verify the prognostic power of the systemic inflammation-based GPS for patients with UTUC with large data across a wide range of disease. The gene discussed is CRP; the disease is renal pelvis/ureter urothelial carcinoma.