When patients with normal ALT were selected (n = 707, 57.0%) to exclude the overestimating influence of high ALT on LS-based prediction models, AUC values of mREACH-B and LSM-HCC were higher than those of PAGE-B (AUC = 0.823–0.730 for mREACH-B, 0.793–0.740 for LSM-HCC vs. 0.734–0.699 for PAGE-B at 3–7 years), but the difference was not statistically significant (all P > 0.05). The gene discussed is GPT; the disease is hepatocellular carcinoma.