Many studies have suggested using the levels of PVT1 expression to predict lymph node metastasis in gastric cancer [24], histological grade and lymph node metastasis in non-small cell lung cancer [31, 32], clinical stage and N-classification in pancreatic cancer [35], and the recurrence rate in HCC [33]. This evidence concerns the gene PVT1 and metastatic malignant neoplasm in the lymph nodes.