As shown in Figure 4B, 13 studies including 1351 patients were enrolled to evaluate the association between TMN stage and PVT1 expression in different cancers, such as gastric cancer (n = 5), hepatocellular carcinoma (n = 2), lung cancer (n = 2), colorectal cancer (n = 1), pancreatic cancer (n = 1), esophageal cancer (n = 1) and bladder cancer (n = 1). The gene discussed is PVT1; the disease is esophageal cancer.