Gli1 expression is correlated with the expression of stemness genes, SOX9, and cell cycle regulators such as p21, cyclin D1, cyclin E1, and NF-κB, which are strongly linked to worse clinical outcome and independent poor prognostic factors in overall survival and disease-free survival in ESCC [19]. Here, NFKB1 is linked to esophageal squamous cell carcinoma.