At 24-72 h after focal cerebral ischemia, phospho-Ptk2b was rapidly induced in microglia surrounding the necrotic infarction area, and phospho-Ptk2b was confirmed to colocalise with phospho-p38 and act as an upstream mediator of the p38 signalling pathway after cerebral ischemia [46]. Here, PTK2B is linked to brain ischemia.