IDH1 and neoplasm: Random survival forest modeling and Cox proportional hazards regression analysis determined imaging habitats 2,7, and 10 to be both important (+ve variable importance) and significant (p-value < 0.05) for determining OS after adjustment for covariates of age, Karnofsky performance score, tumor volume, and IDH1 mutation status (P < 0.05, Supplementary Table 1).