The areas under the curve (AUCs) of RETN and KLK1 were 0.844 (0.783–0.904) and 0.833 (0.769–0.897), respectively, in discriminating TB from the LTBI group, and the AUC values of RETN and KLK1 were 0.908 (0.864–0.951) and 0.853 (0.796–0.911), respectively, in discriminating TB from the HC group. Here, KLK1 is linked to tuberculosis.