In detail, DFS rates at 5 and 10 years were 94.4% and 84.9% vs 98.8% and 94.4% for patients with G3 vs G1-2 breast cancer (hazard ratio=2.53, 95% CI 1.42 to 4.51, p=0.0017, Figure 1A), and 95.4% and 86.8% vs 98.6% and 92.7% for patients with Ki67 ≥20% vs Ki67 < 20% (hazard ratio=2.23, 95% CI 1.24 to 4, p=0.007, Figure 1B), respectively. This evidence concerns the gene MKI67 and breast carcinoma.