EZH2 and colonic neoplasm: Similarly, Nagarsheth et al. [11] found that EZH2 transcriptionally represses the expression and production of CXCL9 and CXCL10 through H3K27 tri-methylation in colon cancer cells, and that overexpression of EZH2 was associated with decreased CD8+ and CD4+ T-cell tumor infiltration as well as poor prognosis in colon cancer patients.