Other than the work performed by the Zou group [10, 11] showing that EZH2 produced by colon cancer cells mediates transcriptional silencing of Th1-type CXCL9 and CXCL10 chemokines, and causes subsequent CD8+ T-cell exclusion, no other studies have systematically explored the potential function of PMTs and PDMTs as one of the key factors of CD8+ T-cell exclusion or antigenicity in solid tumors. Here, CD8A is linked to malignant colon neoplasm.