CD8A and head and neck squamous cell carcinoma: Using a recently described chemokine signature which stratifies CD8+ T-cell inflamed locoregionally advanced SCCHN tumors from non-T-cell inflamed tumors [15, 16], we have interrogated expression levels of PMTs and PDMTs across two large mRNA microarray HPV-negative SCCHN databases in order to identify chromatin modifiers that are positively associated with the non-T-cell inflamed SCCHN phenotype and could thus be biological culprits for CD8+ T-cell exclusion or decreased antigen presentation in HPV-negative SCCHN.