Notably, we found the statistic positive correlation of FEN1 expression with ZBTB3 (r = 0.2093, P < 0.0001) while ZBTB3 expression was positively associated with MTA2 expression (r = 0.3368, P < 0.0001) (Figure 2G), indicating that these genes may be oncogenes and potential drug targets in ESCC. The gene discussed is ZBTB3; the disease is esophageal squamous cell carcinoma.