The results of a large meta-analysis [16] of 6,377 patients with operable or advanced non-metastatic disease from 6 prospective neoadjuvant studies, suggested that pCR is an effective surrogate marker for survival among patients with luminal-B/HER-2 negative, HER-2 positive, and TNBC tumors. The gene discussed is ERBB2; the disease is metastatic neoplasm.