Similarly, Kaplan-Meier analysis indicated that high CD68+ or CD163+ TAM densities were associated with reduced OS (Figure 2A, C; p < 0.001 and p < 0.001, respectively), whereas high iNOS+ TAM densities in MM bone marrow biopsies were associated with increased OS (Figure 2B; p = 0.001). This evidence concerns the gene NOS2 and Miyoshi myopathy.