In fact, a chemotherapy drug previously used to treat brain tumor called etoposide, a topoisomerase II inhibitor, actually mediates glial apoptosis in the C6 glioma cell line via the ceramide pathway by inducing the release of cytochrome c, and leading to the activation of caspase-9 and caspase-3 [39]. Here, CASP3 is linked to brain neoplasm.