DAXX and cancer: Implication of Daxx and Hif1a in DNA hypermethylation and apoptosis [38] has recently emerged, while Hif1a overexpression, as in MCPyV-positive NSCLC samples, has been associated [39] with the formation of cancer-stem-like-like cells undergoing a process of endothelial-mesenchymal transition, both of which are inhibited by miR-21.