In addition, the anti-angiogenesis role of Roflumilast in diffuse large B-cell lymphoma (DLBCL) was also reported, PDE4B repressed cAMP to activate PI3K/AKT signals to up-modulate VEGF secretion and Roflumilast could decreased the microvessel density in lymphoma-bearing mice [25]. The gene discussed is PDE4B; the disease is lymphoma.