In addition, ECM remodeling-related genes, such as ECM components (12 genes: Ctgf, Vcan, Vtn, Col2a1, Col4a3, Col5a1, Ecm1, Sparc, Col1a1, Col3a1, Lama3, and Lamb3) (Figure 7C, middle panel) and metalloproteinases (8 genes: Adamts2, Adamts5, Mmp3, Mmp2, Adamts8, Mmp11, Mmp14, and Mmp15) (Figure 7C, right panel), were also significantly down-regulated in the BLM+ApoJ group compared to those in the BLM+ViaJ group. The gene discussed is COL4A3; the disease is Bloom syndrome.