Since it has been shown that many tumor types express CD146, we screened five cancer cell lines (two metastatic melanoma (UACC-1273 and C8161), a pancreatic (Panc-1) and two colonic (SW620 ad Lovo) cancer cell lines), with TsCD146 mAb and contrasted them with two types of micro and macro-vascular endothelial cells (HMEC-1 and HUVEC) and smooth muscle cells (HUA-SMC) used as a non-diseased control cell types. The gene discussed is MCAM; the disease is neoplasm.