BRCA1 and breast cancer: In terms of familial history, in addition, individuals with any first- or second-degree relatives with OC were associated with positive pathogenic variants of BRCA1/2 or any of the other tested genes in the present study, although most individuals with positive pathogenic variants of BRCA1/2 (15/22, 68.2%) or any of the other tested genes (22/29, 71.0%) did not have a family history of breast cancer/OC.