In contrast, patients with ER-negative tumours with positive membranous PRPF38B expression who received CMF and anthracycline chemotherapy had a higher risk of relapse compared with patients having membranous PRPF38B negative tumours [HR (95% CI) = 2.24 (1.40–3.57); p = 0.001] (Figure 3B(ii)). This evidence concerns the gene PRPF38B and neoplasm.