RT-PCR screening of a panel of normal tissues and tissues obtained from patients with different cancers suggest that levels of PRPF38B are low in the majority of essential organs and that elevated levels of this transcript (above the mean + 2 standard deviations) can be observed in 5/10 patients with kidney cancer, 2/2 patients with gastric cancer, 4/10 patients with prostate cancer and 5/10 individuals with benign prostatic hyperplasia (Supplementary Figure 3). The gene discussed is PRPF38B; the disease is Familial prostate cancer.