In addition to inhibition of bioenergetics, exposure of tumor cells to Gamitrinib or H71-TPP-2 (H71-TPP) triggered apoptosis, characterized by increased Annexin V reactivity, by multiparametric flow cytometry (Figure 6A), and cleavage of effector caspase 3 (Figure 6B), by Western blotting. This evidence concerns the gene CASP3 and neoplasm.