Elevated TRAP1 levels were also observed in adult AML, irrespective of FAB (French-American-British) subtype (M1-M6) or genetic alterations, including 11q23MLL gene rearrangement, CBFB-MYH1 gene fusion, FLT3 mutation, PML-RARα translocation, and RUNX1-RUNX1T1 translocation (not shown). This evidence concerns the gene PML and acute myeloid leukemia.