TP53 and myocardial ischemia: We also proved that CQ10 reduced proapoptotic protein p53, and the ratio of active caspase-3 to procaspase-3 was significantly higher at 2 h, 24 h, and 72 h in rats with acute myocardial ischemia-reperfusion injury than in the control rats (Figure 3; p < 0.05, n = 6).