In addition, quinone derivative 125 directly inhibited the phosphorylation of JAK2 and the downstream phosphorylation of STAT3, especially maximum inhibition occurring at the concentration of 30 μM, together with this compound inducing the reducible activation of ERK1/2, JNK, p38 MAPK, and cAMP response element binding protein (CREB) in a dose-dependent manner, but it caused a concentration-dependent increase of regular JAK2/STAT3 signaling factor phosphatase and tensin homolog deleted on chromosome ten (PTEN) in osteosarcoma cells [48]. This evidence concerns the gene STAT3 and osteosarcoma.