STAT3 and neoplasm: Last but not least, compound 125 reduced colony formation in soft agar and inhibited tumor growth, such as 9 mg/kg; this one significantly decreased by 22.25 ± 11.46% of the tumor weight compared to control in BALB/c athymic nude mice xenograft model in association with the reduced expression of proliferating cell nuclear antigen (PCNA), proliferation marker (Ki67), therapeutic target molecule (p-STAT3), and antiapoptotic molecule (survivin) in tumor tissues [48].