JAK2 and osteosarcoma: As a part of ongoing effort to look for natural products with anticancer effects in vitro and in vivo, recently, Park et al. (2016) mentioned the role of 4-methoxydalbergione (125) in suppressing growth and inducing apoptosis in human osteosarcoma cells in in vitro and in vivo xenograft models through downregulation of the JAK2/STAT3 pathway [48].