Additionally with CBM and β-catenin/TGF-β/INF-γ genes respectively, 4 out of 42 gene pairs (HNF1A-PKP3, VEGFA-DSP, JUN-DST, HNF1A-JUP), 2 out of 42 gene pairs (TGFB2-PPL, CLIC4-DSC3), and 1 out of 42 gene pairs (JAK1-DSP) in lung adenocarcinoma, and 1 out of 42 gene pairs (VEGFA-DST), 5 out of 42 gene pairs (TGFB1-JUP, TGFB1-PKP3, TGFB1-DSC3, SMAD2-DSC3, CLIC4-PKP3), and none of the 42 gene pairs in SCC displayed statistically significant tendency towards co-occurrence (Table S3). The gene discussed is JUP; the disease is lung adenocarcinoma.