LEP and type 1 diabetes mellitus: Here, we demonstrated that: i) circulating sLRP1 is a biomarker of EAT volume in a cohort of well-characterized and well-controlled T1DM patients without clinical cardiovascular disease; ii) the direct relation between the EAT volume and circulating sLRP1 concentration is independent of a number of clinical and metabolic confounders; iii) the association reported between EAT volume and sLRP1 concentration is higher than the observed for other potential biomarkers such as leptin, adiponectin or different inflammatory markers.