STAT3 and neoplasm: After being treated with total dose of 264 μg of STAT3 siRNA, the tumor volume and weight decreased by ~80% compared with the untreated animal (135.57 ± 43.01 mm3vs 704.77 ± 49.36 mm3, 0.16 ± 0.02 g vs 0.80 ± 0.05 g), while being treated with total dose of 132 μg of STAT3 siRNA, the tumor volume and weight decreased by ~50% (361.34 ± 41.47 mm3vs 704.77 ± 49.36mm3, 0.40 ± 0.07 g vs 0.80 ± 0.05 g).