While no human mutations in PIK3C3, the gene encoding Vps34, have been associated with neurodegenerative disorders, the relevance of the PI3P/PI(3,5)P2 pathway in neurological disorders is supported by the existence of amyotrophic lateral sclerosis (ALS) and Charcot–Marie–Tooth 4 J (CMT4J) causing mutations in FIG4 as well as PD causing mutations in VAC14, both of which are key components of the PIKfyve complex controlling PI(3,5)P2 metabolism11,14. This evidence concerns the gene FIG4 and amyotrophic lateral sclerosis.