IKZF3 and acute lymphoblastic leukemia: These alleles augment our current understanding of the genetic etiology of childhood ALL by (i) adding one haplotype that is a strong eQTL for three genes and located at a well-established hematopoietic developmental gene (IKZF3), and (ii) adding an additional locus in a gene-poor region of chromosome 8q24 that is rich with genetic variants affecting risk for myriad different traits.