Compared with the control AMPKα1lox/lox/AMPKα2lox/lox mice injected with GalN/LPS, AMPKα1LS−/− mice was more sensitive to the stimulation of GalN/LPS, manifested by upregulated mortality and shortened survival period, demonstrating that AMPKα1 has an overall beneficial effect in fulminant hepatitis. This evidence concerns the gene GAL and Fulminant hepatitis.