However, when the analysis was restricted to the tumors in proximal colon (Table S5), there were no significant associations between anemia and MMR enzyme status (p = 0.577) or BRAF mutation (p = 0.885), suggesting that the association between proximal tumor location and MMR deficiency (and BRAF mutation) could mainly account for the observed association between MMR deficiency and anemia. Here, MRC1 is linked to mismatch repair cancer syndrome 1.