MRC1 and anemia: However, when the analysis was restricted to the tumors in proximal colon (Table S5), there were no significant associations between anemia and MMR enzyme status (p = 0.577) or BRAF mutation (p = 0.885), suggesting that the association between proximal tumor location and MMR deficiency (and BRAF mutation) could mainly account for the observed association between MMR deficiency and anemia.