We also found a significant decrease of adipose GC-A expression in prediabetic (PreD, defined as impaired fasting glucose or glucose tolerance) and type 2 diabetic subjects (T2D) compared to individuals with normal glucose tolerance (NGT) (Fig. 1D), while no change was observed for NPRC (Fig. 1E). The gene discussed is GCA; the disease is type 2 diabetes mellitus.