KRAS and neoplasm: Thus, to exclude that the observed differences were due to the different tumor burden, we compared PD901-treated K-Ras/NICD liver lysates with pretreated K-Ras/NICD counterparts (i.e., K-Ras/NICD iCCA at 11.7 weeks post injection) that display an equivalent liver load by iCCA lesions (Figs. 5d and 6b).