For shrimp allergy, top variants resided within a similar genomic HLA region encompassing six HLA class II genes (HLA-DQA1, HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DRA), with 60% of high LD SNPs (18/30 SNPs r2 > 0.8) overlapping potential regulatory elements (Supplementary Worksheets S3: 5 promoter marks, 16 enhancers, 2 DHS, 7 TFBS). The gene discussed is HLA-DRB1; the disease is Allergy.