HOXC6 overexpression correlated with high AFP level (P = 0.038), liver cirrhosis (P = 0.044), larger tumor (P = 0.001), vascular invasion (P = 0.046) and Barcelona Clinic Liver Cancer (BCLC) stage (P = 0.005) (Table S1). The gene discussed is HOXC6; the disease is liver cancer.