Consistent with previously proposed biological processes and pathways associated with SSc,3 the upregulated genes showed significant enrichment for unfolded protein response, epithelial mesenchymal transition and DNA repair, whereas the downregulated genes showed enrichment for innate immune response-related processes (figure 1D), such as interferon response and allograft rejection, including genes previously linked to SSc (eg, IL2RB,12TNFAIP3, HLA-DQA1, HLA-DRB13). The gene discussed is IL2RB; the disease is systemic sclerosis.