GSDMA and systemic sclerosis: Our results from differential expression and eQTL analysis in SSc macrophages, when combined with genetic susceptibility (GWAS/WES), regulatory (Roadmap Epigenomics and ENCODE) and expression and eQTL data from the skin and other cell types (GTEx24), support a previously undetected role for macrophages in GSDMA overexpression in the pathogenesis of SSc.