Gasdermins were previously described as regulators of cellular swelling and lysis through formation of membranous pores in conjunction with release of proinflammatory cytokines, a process also known as pyroptosis.29–31 Accordingly, Gsdma3-mutant mice with constitutive pyroptosis display severe skin inflammation.32 Thus, we speculate that overexpression of GSDMA could cause dysregulation of the pyroptosis process in SSc. Here, GSDMA is linked to systemic sclerosis.