To investigate the relationship between SEMA3C expression and EGFR/ErbB2 signaling in clinical PCa samples, we analyzed phosphorylation status of EGFR, ErbB2, and downstream signaling proteins SRC and SHC in high SEMA3C versus low SEMA3C‐expressing samples from The Cancer Genome Atlas (TCGA, http://cancergenome.nih.gov/) prostate adenocarcinoma data set using cBioPortal tools (Cerami et al, 2012; Gao et al, 2013). This evidence concerns the gene EGFR and prostate adenocarcinoma.