Mouse genetics and other studies have found that Plexins A1, A2, and D1 in association with Nrp1 and Nrp2 are receptors for SEMA3C in endothelial cell and glioma stem cells (Epstein et al, 2015; Serini & Tamagnone, 2015). The gene discussed is PLXNA1; the disease is central nervous system cancer.