Since Plexin B1 and D1 are known to mediate RTK activation such as HER2/ErbB2 (Swiercz et al, 2004, 2008; Casazza et al, 2010) and MET (Giordano et al, 2002), we therefore sought to examine whether NRP1, NRP2, Plexin B1, and Plexin D1 are receptors for SEMA3C in PCa cells. This evidence concerns the gene PLXNB1 and posterior cortical atrophy.