Despite this, there is an increasing body of evidence that SLDPQ is tolerated well by both malaria patients and healthy individuals with good pre-treatment haemoglobin (Hb) concentrations in both Southeast Asia [12] and SSA [13] (SAFEPRIM I and II, and PQSAFETY studies; ClinicalTrials.gov identifiers NCT02174900, NCT02654730, and NCT02535767). The gene discussed is GSTM1; the disease is malaria.