Firstly, all the PQ studies that have recruited G6PDd patients have had high baseline Hb concentrations; therefore, we cannot extrapolate with confidence these findings to young symptomatic anaemic P. falciparum-infected children who have lower Hb concentrations (Table 4) and, secondly, the initial reduction in Hb level in PQ-treated asymptomatic P. falciparum carriers is similar to uncomplicated falciparum malaria patients, with some individuals experiencing Hb drops >2 g/dL [36, 37]. Here, GSTM1 is linked to Plasmodium falciparum malaria.