The positive expression rates of UGP2 and CFL1 were significantly lower in cases with high differentiation, no lymph node metastasis, no invasion into the surrounding tissues and organs, and TNM stage I and/or II than in cases with poor differentiation, lymph node metastasis, invasion into the surrounding tissues and organs, and TNM stage III and/or IV (P < 0.05 or P < 0.01). The gene discussed is CFL1; the disease is metastatic malignant neoplasm in the lymph nodes.