The positive expression rates of UGP2 and CFL1 were significantly higher in the pancreatic ductal carcinoma samples than those in the paracancerous tissues (χ2 = 9.426, P = 0.003 and χ2 = 7.786, P = 0.005, respectively), benign lesions (χ2 = 21.647, P = 0.000 and χ2 = 14.275, P = 0.000, respectively), and normal pancreatic tissues (χ2 = 15.874, P = 0.000 and χ2 = 12.973, P = 0.000, respectively). Here, CFL1 is linked to pancreatic ductal adenocarcinoma.