In a Dutch cohort of AML patients treated intensively with anthracycline-based chemotherapy on the Hemato-Oncologie voor Volwassenen Nederland (HOVON) protocols, IRX3 transcripts were detected at high level (i.e., with a probeset [229638_at] value of log2 > 7.1, approximating to a value among the top 25% of array probeset values) in 159 of 461 bulk presentation samples (34%) (Wouters et al., 2009) (Figure 1A). The gene discussed is IRX3; the disease is acute myeloid leukemia.