IRX3 and acute lymphoblastic leukemia: To identify transcription factor genes concordantly expressed with IRX3 in T-ALL, we compared IRX3high (array signal intensity > 0.42, n = 84) with IRX3low (array signal intensity < 0.3, n = 78) cases and observed that only HOXA genes were upregulated by greater than a mean 2-fold change in array signal intensity (and with p < 10−5, by unpaired t test) (Figure 7B).