Analysis of 8,954 protein-coding genes that passed threshold criteria (i.e., expression >0.5 reads per kilobase per million mapped reads [RPKM] in at least one sample) revealed that 197 were upregulated and 403 downregulated by at least 2-fold in Hoxa9/IRX3 versus Hoxa9/MTV leukemias (Figure 5A). The gene discussed is HOXA9; the disease is leukemia.