We ranked protein-coding genes in IRX3high versus IRX3low human AMLs (Wouters et al., 2009) using a signal-to-noise ranking metric (Table S6) and performed GSEA using the set of genes repressed by IRX3 in murine Hoxa9/IRX3 AML cells (Table S5). The gene discussed is IRX3; the disease is acute myeloid leukemia.