IRX3 and acute lymphoblastic leukemia: In a cohort of T-ALL patients (Microarray Innovations in Leukemia [MILE] study; Haferlach et al., 2010), IRX3 transcripts were detected at high level (i.e., with a probeset [229638_at] value of ≥ 0.42, approximating to a value among the top 25% of array probeset values) in 84 of 174 cases (48%) (Figure 7A).