High HOXA expression is a feature of human T-ALL associated with CALM-AF10 fusions, SET-NUP214 fusions, MLL gene rearrangements, or inv(7) or t(7;7) translocations (resulting in apposition of the HOXA locus to TCR-β regulatory elements; Soulier et al., 2005, Van Vlierberghe et al., 2008). The gene discussed is NUP214; the disease is acute lymphoblastic leukemia.