On the other hand, untargeted lipidomics analysis showed that phospholipids of specific molecular species were significantly reduced in the colonic epithelium from young obese mice (Table S3B), in keeping with obesity-associated dysregulation of phospholipid metabolism genes, such as Lpcat1 and Lpcat4 (Table S2A). This evidence concerns the gene LPCAT4 and obesity due to melanocortin 4 receptor deficiency.