COL2A1 and Stickler syndrome: For example Stickler's syndrome is most commonly associated with defects in the gene for collagen type II alpha-1 (COL2A1), which is expressed in the sclera, a structure that displays significant alterations in myopia.22,23 What has been lacking to date is a comprehensive analysis of the genetic basis of syndromic myopia and its potential broader relevance to refractive error development.