ZNF146 and brittle cornea syndrome: While none of these genes showed a significant association with refractive error in the VEGAS analysis of the CREAM GWAS dataset, ZNF644 at the MYP21 locus is a member of the Krüppel C2H2-type zinc-finger protein family, and another member of this family, ZNF469, causes type 1 brittle cornea syndrome, which features blue sclera and myopia.