Moreover, Braitch et al. reported that OPN levels were positively correlated with the relative presence of Th1 cytokine, IL12p40, in the CSF of patients with MS [28].Chabas et al. suggested that OPN may have an important role in MS pathology by Th1 response regulation; they showed that while production of IL-10 was increased in OPN-/- mice, INF-γ and IL-12 productions were diminished compared to OPN+/+ ones [21]. Here, SPP1 is linked to myeloid sarcoma.